When it comes to feeling your best both mentally and physically there are two systems that quietly coincide: our brain and our gut.
More than we realize, these two main functions within our body work together. They influence everything from focus to mood to digestion to immune health. While diet, sleep, and stress all play an important role too, certain supplements give these systems the extra support they need.
Two standouts? Creatine for brain energy and L-Glutamine for gut health.
Our brain and gut are constantly talking to each other through the gut-brain axis. This means the health of our gut directly impacts our mood, focus, energy and mental clarity and vice versa.
At Volare Nutrition, we’re passionate about the brain-gut connection. One of our goals is to create products that support this vital link, helping our bodies achieve true balance while staying resilient against the stresses of the outside world.
Creatine has recently been in the spotlight. It has always been an important supplement in the fitness world but now has become a hot topic in longevity and brain health.
While long known for its muscle-building benefits, research now shows that creatine can elevate brain phosphocreatine levels, boost ATP production, and may enhance memory, processing speed, and mood. The studies are promising especially during times of stress, lack of sleep, aging, or even as a supportive therapy in depression.
L‑Glutamine supports the gut lining, immune cells, and reduces intestinal permeability. L-Glutamine is key for people with high stress, heavy training, IBS/SIBO, or increased gut permeability.
Together, Creatine + L-Glutamine target the gut–brain axis from both sides: brain bioenergetics (creatine) + gut barrier & immune support (glutamine).
Why Creatine Belongs in Brain Health
Most people know creatine is used for strength and power. Our brain also relies on rapid ATP recycling. Supplementation of creatine can increase brain creatine levels to help:
L‑Glutamine: Fuel for Your Gut and an Indirect Brain Support
Our gut lining cells love glutamine. It's their preferred fuel source. The supplementation of L-Glutamine can help:
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Glutamine helps keep our immune system strong because it needs a lot of it to keep us staying active and healthy
Fact: Because the gut–brain axis is bi-directional, improving the gut barrier strength and lowering inflammatory “noise” can indirectly benefit our brain function, mood, and stress resilience.
The Top-Down + Bottom-Up Strategy
╰┈➤ Creatine: Boosts brain energy, supports our mood while under stress, and studies show that it may protect brain health (lots of research underway!)
╰┈➤ L‑Glutamine: Strengthens the gut lining, supports our immune support and helps reduce inflammation that in turn can affect our brain (not for all but for some, like Co-Owner Lisa!).
Together, Creatine and L-Glutamine stabilize brain energy metabolism while supporting the gut barrier that communication to the brain.
Who Might Benefit The Most?
- High stress, or nervous system overload, sleep-deprived, or overworked (we all feel stress differently so be in tune with your body)
- Older adults or vegans/vegetarians as studies show they show larger cognitive responses to creatine supplements.
- Athletes or anyone with heavy training loads. Intense workouts 5-7 days a week with little rest - "intense" depends on how hard you’re training, how well you recover. Everybody is different so your intense may be different than someone else's intense.
- People with IBS/SIBO
How to Use Them (Typical Evidence-Informed Ranges)
Creatine Monohydrate: 5-10 g/day (consistency is key, not timing). No loading phase required. Check out this study for more information on increased 10-20g per day for older adults and brain health.
L‑Glutamine: 5 g 1–3×/day for regular gut support and repair. For those of us, like co-owner Lisa with gut challenges like SIBO or IBS, research suggests that higher doses of L-glutamine of ~ 20 g per day can be beneficial for a short time period. This therapeutic approach helps repair the gut lining, reduce permeability, and calm inflammation before you go into a maintenance dose.
**Just a reminder, always check with your clinician if you have medical conditions, are pregnant/breastfeeding, or take medications. This is not medical advice as we are all different.
Why Try Volare's Creatine + L-Glutamine
Power up your brain and strengthen your gut with one highly research-backed formula. Our duo targets two critical systems, our brain energy and our gut integrity so you get the benefits of two supplements in one simple supplement.
The science is strong (and growing) for creatine’s role in brain energy/mood and glutamine’s role in intestinal permeability and immune support, making them a smart combo for the gut–brain era of wellness.
